Research Interests
Caoimhe’s scientific research is interdisciplinary and built around the key themes of medicinal chemistry and drug transportation. Her research utilises modern biotechnology to understand the expression and activity of key transporter proteins and their role in the pathology of various inflammatory diseases.
Caoimhe is a member of the American Association of Pharmaceutical Scientist (AAPS), the American Physiological Society and COST Action. Caoimhe is also the proud recipient of Trinity College Post-graduate Scholarship which aims to merit students based on academic merit.
Public outreach & key achievements
Tobacco Smoke and Inhaled Drugs Alter Expression and Activity of Multidrug Resistance-Associated Protein-1 (MRP1) in Human Distal Lung Epithelial Cells in vitro. Mohammed Ali Selo1,2*, Anne-Sophie Delmas1, Lisa Springer1, Viktoria Zoufal1,3, Johannes A. Sake1, Caoimhe G. Clerkin1, Hanno Huwer4, Nicole Schneider-Daum5, Claus-Michael Lehr5,6, Sabrina Nickel1, Oliver Langer3,7,8 and Carsten Ehrhardt1* Front. Bioeng. Biotechnol., 08 September 2020 | https://doi.org/10.3389/fbioe.2020.01030
Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro.
Nickel, Sabrina; Selo, Mohammed Ali; Fallack, Juliane; Clerkin, Caoimhe G; Huwer, Hanno; Schneider-Daum, Nicole; Lehr, Claus-Michael; Ehrhardt, Carsten. Pharmaceutical Research, Vol. 34, No. 12, 01.12.2017, p. 2477-2487.
Transport mechanisms at the pulmonary mucosa : implications for drug delivery. Nickel, Sabrina; Clerkin, Caoimhe G; Selo, Mohammed Ali; Ehrhardt, Carsten. Expert Opinion on Drug Delivery, Vol. 13, No. 5, 24.02.2016, p. 667-90.
Presentations Title:
Student Centred Teaching and Learning (The Queen’s Partnership Programme). C.Clerkin, M.Malekigorji. Advance HE STEM, Manchester, UK. 29th-30th January 2020.
Bile acids regulate expression of Aryl Hydrocarbon Receptor in colonic epithelial cells. Europhysiology Conference, C. Clerkin, J. Smyth, C. Fallon, N. Lajczak, S. Keely. London, UK, 14-16th September 2018
Aromatic Substitution Reaction of Ergothioneine Might be a Novel Mechanism of Xenobiotic Deactivation. C.Clerkin, Matzinger M, Selo MA, Talbot B, Walsh JJ, Ehrhardt C.Experimental Biology, Chicago, April 2017
Studies on the functional expression of MRP1 and BCRP in lung epithelial cells in vitro. Sabrina Nickel, C. Clerkin, Mohammed A. Selo, Matthias Meinhardt, Simon Higgins, Juliane Fallack, Carsten Ehrhardt. American Association Pharmaceutical Society, Orlando, October 2015
The detection of non-radiolabelled ergothioneine by liquid chromatography tandem mass spectrometry. C. Clerkin, C. Ehrhardt. 17th Barrier and Transporter Meeting. Bad Herrenalb, Germany. May 2015
The quantification of the antioxidant amino acid ergothioneine in distal lung epithelial cells by ultra-high liquid chromatography- tandem mass spectrometry. C. Clerkin, C. Ehrhardt. All Ireland Schools of Pharmacy Conference Queens University, Belfast, 30 March 2015.
Alumni: Where are they now